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Case Report
Intracholecystic papillary neoplasm in a child: A case report
1 Loma Linda University School of Medicine, Loma Linda, CA, USA
2 Department of Surgery, Division of Pediatric Surgery, Loma Linda University Health, Loma Linda, CA, USA
3 Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA
Address correspondence to:
Vinicius Silva
24920 Mound St., Loma Linda, CA 92350,
USA
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Article ID: 100163Z12VS2025
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How to cite this article
Silva V, McRae J, Deisch J, Mladenov G, Kashtan M, Mejaddam A. Intracholecystic papillary neoplasm in a child: A case report. J Case Rep Images Surg 2025;11(2):24–28.ABSTRACT
Introduction: Gallbladder (GB) cancer is a well-studied neoplasia that occurs within the mucosal lining of the gallbladder. More recently, a pre-invasive lesion of the gallbladder, known as intracholecystic papillary neoplasm (ICPN), has been described in the literature. Intracholecystic papillary neoplasm is rare in the adult population and is commonly found incidentally after cholecystectomy. In pediatric care, only one such case has previously been documented.
Case Report: Our patient, an 11-year-old male with a history of immunosuppressant use for nephrotic syndrome, presented with symptoms suspicious for choledocholithiasis. He was found to have ICPN on histopathological analysis after cholecystectomy. Post-operative course was notable for biliary obstruction due to hemobilia that required endoscopic retrograde cholangiopancreatography (ERCP) with stent placement.
Conclusion: Cholecystectomy and scheduled follow-up are a suitable way of preventing the progression of ICPN. Pediatric patients should also be considered for genetic testing.
Keywords: Choledocholithiasis, Immunosuppression, Intracholecystic papillary neoplasm, Pediatric
SUPPORTING INFORMATION
Author Contributions
Vinicius Silva - Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Joyce McRae - Substantial contributions to conception and design, Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Jeremy Deisch - Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Georgi Mladenov - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mark Kashtan - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ali Mejaddam - Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
AcknowledgmentsArtificial intelligence (AI) uses in the article: No artificial intelligence has been used in any part of the creation or revision of this manuscript.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Vinicius Silva et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
